Table 1.
Patient characteristics n (%)
| < 65 yr (n = 38) | 65-75 yr (n = 41) | ≥ 75 yr (n = 23) | P value | HR (95%CI) | |
| Age group multivariate HR (95%CI)1 | 1 | 1.03 (0.58-1.83) | 1.04 (0.56-1.9) | - | |
| Female | 35 (92.2) | 24 (58.6) | 16 (69.6) | 0.003 | 0.55 (0.31-0.98)1 |
| Cirrhosis at diagnosis | 35 (92.1) | 41 (1) | 22 (95.6) | 0.338 | |
| Ascites at diagnosis | 4 (10.5) | 4 (9.7) | 4 (17.3) | 0.632 | |
| Hepatitis B virus | 12 (31.5) | 7 (17.0) | 2 (8.6) | 0.06 | 0.85 (0.49-1.47)1 |
| Hepatitis C virus | 21 (55.2) | 29 (70.7) | 18 (78.2) | 0.14 | |
| Cancer of the Liver Italian Program2 | 0.008 | ||||
| 0 | 8 (21.0) | 20 (48.7) | 7 (30.4) | 1.9 (1.5-2.4)2 | |
| 1 | 6 (15.7) | 13 (31.7) | 9 (39.1) | ||
| 2 | 17 (44.7) | 8 (19.5) | 5 (21.7) | ||
| 3 | 6 (15.7) | 0 (0.0) | 2 (8.6) | ||
| 4 | 1 (2.6) | 0 (0.0) | 0 (0.0) | ||
| Okuda2 | 0.001 | ||||
| 1 | 21 (55.2) | 39 (95.1) | 19 (82.6) | 5 (2.7-9.1)2 | |
| 2 | 16 (42.1) | 2 (4.8) | 4 (17.3) | ||
| 3 | 1 (2.6) | 0 (0.0) | 0 (0.0) | ||
| Child-Pugh-Turcot2 | 0.98 | ||||
| 1 | 31 (81.5) | 35 (85.3) | 19 (82.6) | 2.1 (1.2-3.6)2 | |
| 2 | 6 (15.7) | 5 (12.1) | 3 (13.0) | ||
| 3 | 1 (2.6) | 1 (2.4) | 1 (4.3) | ||
| Barcelona Clinic Liver Cancer | 0.027 | ||||
| 1 | 3 (7.8) | 15 (36.5) | 3 (13.0) | 2.3 (1.65-3.2)2 | |
| 2 | 7 (18.4) | 6 (14.6) | 5 (21.7) | ||
| 3 | 26 (68.4) | 19 (46.3) | 15 (65.2) | ||
| Procedures | 0.16 | ||||
| 1 | 12 (31.5) | 4 (9.7) | 7 (30.4) | ||
| 2 | 12 (31.5) | 12 (29.2) | 8 (34.7) | ||
| 3 | 6 (15.7) | 11 (26.8) | 2 (8.6) | ||
| > 3 | 8 (20.9) | 14 (31.4) | 6 (26.0) | ||
| Number of procedures | 2.4 ± 1.6 | 3.4 ± 2.0 | 2.7 ± 2 | 0.07 | |
| Albumin at diagnosis | 36.37 ± 4.4 | 36.3 ± 4.7 | 36.0 ± 5.2 | 0.96 | 0.97 (0.84-1.11)1 |
| Alpha-fetoprotein at diagnosis | 944 ± 2162 | 337 ± 729 | 9232 ± 31376 | 0.05 | |
| International normalized ratio at diagnosis | 1.14 ± 0.23 | 1.19 ± 0.25 | 1.12 ± 0.18 | 0.46 | 11 |
| Bilirubin at diagnosis | 2.9 ± 7.8 | 1.02 ± 0.66 | 1.17 ± 0.56 | 0.19 |
1
Hazard ratio (HR) (95%CI) when controlling for Barcelona Clinic Liver Cancer (BCLC) in multivariate model;
2
Multivariate HRs used instead of BCLC.