Table 3.

Conditions and safety considerations that should preclude specific drug choice during IM treatment of agitation in emergency settings due to fatality risk.

Condition	Safety consideration	Drug to avoid
Alcohol abuse/intoxication	Possible respiratory distress	BDZs
Opioid intoxication	Possible respiratory distress	BDZs
General medical condition affecting resp. funct	Possible respiratory distress	BDZs
General medical condition affecting card. funct	Cardiovascular risk	FGAs
No informations	Possible cardiovascular/Qtc affect. cond.	Haloperidol
Impossible assessment of resp. function	Possible respiratory distress	BDZs
Delirium	Possible worsening	BDZs
Stimulants intoxication	Cardiovascular risk	FGAs
Impaired renal function/cocaine	Propylene glycol toxicity	lorazepam, diazepam
BDZs pre-treatment	Cardiorespiratory depression	Olanzapine