Table 4.

Basic pharmacokinetic profile of discussed IM drugs (Goodman et al., 2006; *Smith et al., 1981).

Drug	Plasma peak time	Elimination pathway	Half-life (average)	Active metabolites
Haloperidol	20′	Hepatic	24 h	Hydroxy-haloperidol
Chlorpromazine	15’	Hepatic	15–30 h	7-Hydroxychlorpromazine chlorpromazine N-oxide (possibile)
Lorazepam	2–6 h	Hepatic	10–20 h	None
Diazepam	1, 5 h	Hepatic, renal	4–6 h	Desmethyldiazepam, oxazepam
Midazolam*	24′	Hepatic	1–3 h	None
Olanzapine	5-8 h	Hepatic	21–54 h	None
Ziprasidone	6, 6 h	Hepatic	6–8 h	S-methyldihydroziprasidone
Aripiprazole	3–5 h	Hepatic	75–146 h	Dehydroaripiprazole