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. Author manuscript; available in PMC: 2013 May 7.
Published in final edited form as: Per Med. 2011 May 1;8(3):331–345. doi: 10.2217/pme.11.16

Figure 1. EGF receptor signaling pathway.

Figure 1

Upon activation by extracellular ligands, EGF receptor dimerizes and autophosphorylates. This leads to activation of RAS, which then complexes with RAF. The RAS/RAF complex then phosphorylates and thereby activates MEK. MEK in turn phosphorylates MAPK/ERK. Phosphorylation of multiple nuclear transcription factors by activated MAPK/ERK ultimately leads to DNA synthesis and cell proliferation.