Fig. 5.

Myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in the lung of pancreatitic rats. Sample was obtained after induction of severe acute pancreatitis (SAP) at the corresponding time-points. (a,c) Effects of ethyl pyruvate (EP) on MDA concentration in the lung of rats with SAP. Pulmonary MDA concentration was significantly lower in EP-treated rats than in SAP rats at 6 h after the induction of SAP. (b,d) Lung neutrophil infiltration as measured by MPO activity. MPO activity was increased significantly in the lung from taurocholate-treated rats in comparison to control rats. The treatment with EP reduced the taurocholate-induced increase of MPO activity significantly in the lung at 6 h after the induction of SAP. Bars represent the means ± standard error of 12 rats. *P < 0·05 versus control group and †P < 0·05 versus SAP group, as tested by one-way analysis of variance (anova). Cont: control.