Fig. 9.

Effect of ethyl pyruvate (EP) on the increase in specific binding of p50 and p65 to DNA in the lung. (a) Changes of p50/p65 DNA binding activity in the lung after induction of severe acute pancreatitis (SAP)at the corresponding time-points. (b) Rats undergoing SAP were treated with EP or vehicle solution. Nuclear fractions were harvested 6 h following taurocholate administration from rats with or without EP treatment (n = 12 for each group). The DNA binding activity assay showed a marked decrease in the p50/p65 binding activity in nuclear fractions from lung tissue in the EP-treated group. Values are shown as means ± standard error. *P < 0·05 compared with control group and †P < 0·05 compared with SAP group. Cont: control.