Table 1.
Comparison of ‘high’ and ‘normal’ cerebrospinal fluid (CSF) CXCL10 concentration groups from all opsoclonus–myoclonus syndrome (OMS) cross-sectional data.
| OMS | ||||
|---|---|---|---|---|
| Controls | ‘High’ | ‘Normal’ | ||
| n | 81 | 48 | 197 | P-value |
| Clinical variables | ||||
| Age (year) | 4·7 ± 3·1 | 3·8 ± 2·2 | 4·4 ± 3·6 | 0·26 |
| Gender ratio (male : female) | 39:42 | 21:27 | 89:108 | 0·87 |
| OMS onset (year) | – | 2·3 ± 1·5 | 1·8 ± 1·0 | 0·01* |
| OMS duration (year) | – | 1·5 ± 2·1 | 2·5 ± 3·7 | 0·06 |
| OMS severity (TS) | – | 14·5 ± 7·7 | 13·0 ± 8·1 | 0·29 |
| Laboratory variables | ||||
| CSF leucocytes/cu mm | 1·2 ± 1·2 | 5·9 ± 10·2 | 1·9 ± 3·0 | < 0·0001*† |
| CSF lymphocyte subsets (%) | ||||
| NK | 7·0 ± 4·2 | 3·7 ± 1·9 | 4·8 ± 3·3 | < 0·0001*† |
| CD19+CD3– | 1·9 ± 2·1 | 4·0 ± 3·7 | 2·9 ± 3·1 | < 0·0001*† |
| CSF cytokines (pg/ml) | ||||
| BAFF (CSF) | 144 ± 88 | 223 ± 184 | 124 ± 73 | < 0·0001*† |
| CXCL13 (CSF) | 1·7 ± 5·2 | 21 ± 42 | 4·1 ± 5·8 | < 0·0001*† |
| CXCL9 (serum) | 79 ± 83 | 103 ± 240 | 59 ± 78 | 0·09 |
| CXCL10 (serum) | 109 ± 51 | 259 ± 399 | 113 ± 66 | 0·001*† |
| CXCL11 (serum) | 37 ± 59 | 105 ± 177 | 31·0 ± 45·3 | 0·005* |
| CSF OCB-positive (%) | 0 | 50 | 31 | 0·21 |
| CSF OCB no. | 0 | 2·9 ± 3·2 | 1·7 ± 2·9 | 0·08 |
| CSF CD4+CXCR3+ (%) | 61 ± 22 | 73 ± 26 | 77 ± 12 | 0·42 |
| Blood CD4+CXCR3+ (%) | 13·7 ± 4·7 | 16 ± 7 | 19 ± 9 | 0·26 |
Significant, but uncorrected, P values.
The Bonferroni correction was calculated separately for clinical variables (P < 0·01) and for laboratory variables (P < 0·004). Except for categorical variables, data are means ± standard deviation; n for oligoclonal bands (OCB) in controls was 17. Three-group comparisons were made by analysis of variance (anova) and two-group comparisons by t-tests, except for ratios, which were analysed by χ2. For all significant anovas, post-hoc comparisons of means were significant at the *** level between controls versus ‘high’, as well as ‘high’ versus ‘normal’, except for serum CXCL10 and CXCL11, which were at the ** level of significance. Also the % natural killer (NK) cells was higher in controls than OMS, but not between OMS groups. BAFF: B cell activating factor BAFF; CSF: cerebrospinal fluid.