Table 2.
Association between personal history of allergic and immune-related disorders and: (a) FCD and (b) asthma among controls.
| Controls* | FCD cases* | Controls no asthma‡ | Controls asthma‡ | |||||
|---|---|---|---|---|---|---|---|---|
| n = 539 | n = 279 | n = 421 | n = 133 | |||||
| Personal history | n (%) | n (%) | adj OR† for FCD (95% CI) | P-value | n (%) | n (%) | adj OR§ for asthma (95% CI) | P-value |
| Asthma¶ | 127 (23·7) | 70 (25·5) | 1·15 (0·81–1·64) | 0·43 | – | – | – | |
| Eczema¶ | 103 (19·3) | 52 (18·9) | 0·99 (0·68–1·43) | 0·99 | 59 (14·1) | 50 (37·9) | 4·17 (2·61–6·68) | <0·0001 |
| Hayfever¶ | 236 (44·3) | 106 (38·4) | 0·84 (0·62–1·14) | 0·27 | 159 (37·9) | 90 (69·2) | 3·70 (2·37–5·77) | <0·0001 |
| Rheumatoid arthritis | 10 (1·9) | 4 (1·5) | 0·70 (0·21–2·32) | 0·56 | 9 (2·2) | 1 (0·7) | 0·32 (0·04–2·57) | 0·28 |
| Chronic fatigue syndrome | 11 (2·1) | 11 (4·0)** | 3·11 (1·11–8·71) | 0·03 | 7 (1·7) | 4 (3·1) | 1·73 (0·42–7·15) | 0·45 |
*
Matched FCD cases and controls with complete data.
†
Matched odds ratios adjusted (adjOR) for level of education and ever smoker.
‡
All interviewed controls with allergy data, including those not matched to a participating case.
§
OR adjusted for age, gender, level of education and ever smoker.
¶
Prior to FCD onset.
**
None of these 11 FCD cases were classified as ‘primary progressive multiple sclerosis’. FCD: a first clinical diagnosis of central nervous system demyelination; CI: confidence interval.