Table 5.

Association between family history of allergic and autoimmune disorders and: (a) FCD and (b) asthma among controls.

	Controls*	FCD cases*			Controls no asthma‡	Controls asthma‡
	n = 539	n = 279			n = 421	n = 133
Family history	n (%)	n (%)	adj OR† for FCD (95% CI)	P-value	n (%)	n (%)	adj OR§ for asthma (95% CI)	P-value
Asthma: mother	75 (14·8)	36 (13·8)	0·92 (0·59–1·43)	0·71	49 (12·2)	30 (25·9)	2·81 (1·65–4·77)	<0·0001
Asthma: father	51 (10·3)	26 (10·4)	0·94 (0·56–1·57)	0·82	31 (8·0)	21 (18·3)	2·42 (1·31–4·48)	0·005
Asthma: sibling¶	147 (29·8)	61 (23·9)	0·77 (0·53–1·12)	0·17	94 (24·4)	54 (45·0)	3·02 (1·90–4·79)	<0·0001
Hayfever: mother	145 (30·0)	73 (28·2)	0·96 (0·67–1·38)	0·84	106 (27·5)	41 (37·6)	1·76 (1·10–2·80)	0·02
Hayfever: father	90 (19·3)	44 (18·3)	0·97 (0·63–1·49)	0·89	57 (15·3)	33 (31·1)	2·55 (1·52–4·29)	<0·0001
Hayfever: sibling¶	207 (43·6)	95 (37·9)	0·78 (0·55–1·10)	0·16	151 (40·3)	62 (55·9)	2·29 (1·45–3·64)	<0·0001
Rheumatoid arthritis**	84 (17·7)	40 (16·3)	0·88 (0·56–1·40)	0·60	64 (17·1)	23 (20·2)	1·04 (0·60–1·84)	0·88
Multiple sclerosis**	5 (1·0)	11 (4·3)	4·15 (1·42–12·2)	0·009	4 (1·1)	2 (1·7)	2·26 (0·37–13·82)	0·38
Autoimmune thyroiditis**	20 (4·2)	9 (3·7)	0·91 (0·38–2·20)	0·83	16 (4·2)	4 (3·4)	0·76 (0·25–2·34)	0·63
Inflammatory bowel disease**	35 (7·2)	23 (9·0)	1·49 (0·84–2·66)	0·17	26 (6·8)	10 (8·3)	1·42 (0·65–3·07)	0·38

^*Matched FCD cases and controls with complete data.

^†Matched odds ratios adjusted (_adjOR) for level of education and ever smoker.

^‡All interviewed controls with allergy data, including those not matched to a participating case.

^§OR adjusted for age, gender, level of education and ever smoker.

^¶Additionally adjusted for sibship size.

^**Mother, father and/or sibling had history of disorder. FCD: a first clinical diagnosis of central nervous system demyelination; CI: confidence interval.