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. 2013 Jun;54(6):1531–1540. doi: 10.1194/jlr.M031591

Fig. 2.

Fig. 2.

Insulin increases SREBP-1c mRNA expression in a time- and concentration-dependent manner. A: Time course of insulin-regulated SREBP-1c mRNA expression. Differentiated adipocytes were starved in serum/Dex/insulin-free maintenance medium for 16 h and then incubated in serum/Dex-free maintenance medium in the presence or absence of 100 nM insulin for the indicated times. B: Concentration-response effect of insulin on SREBP-1c mRNA expression. Differentiated adipocytes were starved in serum/Dex/insulin-free maintenance medium for 16 h and then incubated in serum/Dex-free maintenance medium in the presence or absence of insulin at the indicated concentrations for 24 h. The mRNA expression levels of SREBP-1c were measured by quantitative real-time PCR. Data are presented as means ± SEM of three independent experiments. *P < 0.05, **P < 0.01.