Table 3.
Hazard ratios (95% CIs) for quintiles of total folate, vitamin B-12, and vitamin B-6 intake over nine years of dementia or AD incidence
| Quintiles of Total Folate Intake | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | p-trend | |
| Dementia | ||||||
| Model 1 | Ref | 1.07 (0.78, 1.49) | 0.89 (0.64, 1.25) | 0.99 (0.72, 1.37) | 1.01 (0.73, 1.40) | 0.86 |
| Model 2 | Ref | 1.05 (0.76, 1.45) | 0.90 (0.64, 1.33) | 0.96 (0.69, 1.33) | 0.98 (0.70, 1.36) | 0.71 |
| Model 3 | Ref | 1.02 (0.67, 1.57) | 0.87 (0.53, 1.45) | 1.13 (0.60, 2.12) | 1.42 (0.69, 2.88) | 0.45 |
| AD | ||||||
| Model 1 | Ref | 1.26 (0.83, 1.94) | 0.94 (0.60, 1.47) | 1.10 (0.72, 1.70) | 1.16 (0.75, 1.80) | 0.76 |
| Model 2 | Ref | 1.21 (0.79, 1.85) | 0.91 (0.58, 1.43) | 1.02 (0.66, 1.58) | 1.07 (0.69, 1.67) | 0.93 |
| Model 3 | Ref | 1.14 (0.71, 1.84) | 0.95 (0.54, 1.66) | 1.36 (0.68, 2.72) | 1.75 (0.80, 3.83) | 0.23 |
| Quintiles of Total B-12 Intake | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | p-trend | |
| Dementia | ||||||
| Model 1 | Ref | 1.00 (0.66, 1.52) | 1.28 (0.88, 1.86) | 0.88 (0.58, 1.33) | 0.94 (0.63, 1.40) | 0.60 |
| Model 2 | Ref | 0.98 (0.65, 1.49) | 1.24 (0.85, 1.81) | 0.85 (0.56. 1.28) | 0.90 (0.60, 1.35) | 0.47 |
| Model 3 | Ref | 0.93 (0.60, 1.46) | 1.14 (0.74, 1.74) | 0.83 (0.49, 1.39) | 0.87 (0.52, 1.46) | 0.56 |
| AD | ||||||
| Model 1 | Ref | 0.96 (0.62, 1.47) | 1.00 (0.63, 1.57) | 1.28 (0.85, 1.92) | 0.92 (0.59, 1.44) | 0.98 |
| Model 2 | Ref | 1.01 (0.64, 1.59) | 1.29 (0.86, 1.95) | 0.92 (0.59, 1.44) | 0.99 (0.64, 1.53) | 0.84 |
| Model 3 | Ref | 0.95 (0.58, 1.54) | 1.14 (0.71, 1.81) | 0.87 (0.50, 1.53) | 0.91 (0.52, 1.60) | 0.72 |
| Quintiles of Total B-6 Intake | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | p-trend | |
| Dementia | ||||||
| Model 1 | Ref | 0.79 (0.53, 1.17) | 0.78 (0.53, 1.15) | 0.80 (0.54, 1.19) | 0.82 (0.55, 1.21) | 0.36 |
| Model 2 | Ref | 0.76 (0.51, 1.14) | 0.75 (0.51, 1.11) | 0.75 (0.50, 1.12) | 0.78 (0.52, 1.15) | 0.24 |
| Model 3 | Ref | 0.74 (0.48, 1.14) | 0.62 (0.38, 1.03) | 0.69 (0.36, 1.34) | 0.67 (0.34, 1.30) | 0.28 |
| AD | ||||||
| Model 1 | Ref | 0.86 (0.56, 1.32) | 0.87 (0.57, 1.32) | 0.85 (0.55, 1.31) | 0.85 (0.55, 1.31) | 0.56 |
| Model 2 | Ref | 0.82 (0.53, 1.27) | 0.82 (0.54, 1.25) | 0.79 (0.51, 1.22) | 0.82 (0.53, 1.26) | 0.37 |
| Model 3 | Ref | 0.79 (0.49, 1.27) | 0.62 (0.36, 1.07) | 0.61 (0.30, 1.27) | 0.58 (0.27, 1.21) | 0.16 |
Model 1- unadjusted; Model 2- adjusted for gender, education; Model 3- fully adjusted for gender, education, bmi (cont), total kcals (cont), physical activity, apoe, alcohol, smoking, MI, stroke, DM, and the other B-vitamins in quartiles and treated as a continuous variables (17 = df).