Table 4.
Hazard ratios (95% CIs) for quintiles of food folate and vitamin B-6 intake over nine years of dementia or AD incidence
| Quintiles of Food Folate Intake | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | p-trend | |
| Dementia | ||||||
| Model 1 | Ref | 0.73 (0.51, 1.04) | 1.08 (0.79, 1.48) | 1.04 (0.75, 1.42) | 0.93 (0.67, 1.28) | 0.68 |
| Model 2 | Ref | 0.71 (0.50, 1.01) | 1.07 (0.78, 1.47) | 1.01 (0.73, 1.38) | 0.89 (0.64, 1.24) | 0.84 |
| Model 3 | Ref | 0.63 (0.40, 1.01) | 0.97 (0.64, 1.47) | 0.99 (0.64, 1.51) | 0.86 (0.55, 1.35) | 0.82 |
| AD | ||||||
| Model 1 | Ref | 0.86 (0.57, 1.32) | 0.72 (0.46, 1.13) | 1.03 (0.69, 1.55) | 0.99 (0.66, 1.49) | 0.23 |
| Model 2 | Ref | 0.80 (0.50, 1.27) | 1.15 (0.75, 1.75) | 1.07 (0.69,1.64) | 1.04 (0.68, 1.60) | 0.47 |
| Model 3 | Ref | 0.76 (0.46, 1.27) | 1.10 (0.69, 1.75) | 1.16 (0.72, 1.86) | 1.02 (0.62, 1.67) | 0.43 |
| Quintiles of Food B-12 Intake | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | p-trend | |
| Dementia | ||||||
| Model 1 | Ref | 1.07 (0.77, 1.48) | 0.95 (0.67, 1.34) | 1.33 (0.96, 1.83) | 1.00 (0.72, 1.38) | 0.58 |
| Model 2 | Ref | 1.11 (0.80, 1.54) | 0.94 (0.67, 1.34) | 1.36 (0.99, 1.87) | 1.01 (0.73, 1.40) | 0.58 |
| Model 3 | Ref | 1.13 (0.73, 1.75) | 0.84 (0.52, 1.36) | 1.30 (0.84, 2.01) | 0.90 (0.60, 1.37) | 0.79 |
| AD | ||||||
| Model 1 | Ref | 0.95 (0.61, 1.46) | 0.72 (0.45, 1.16) | 1.36 (0.91, 2.04) | 1.09 (0.73, 1.63) | 0.26 |
| Model 2 | Ref | 1.10 (0.65, 1.55) | 0.72 (0.45, 1.16) | 1.37 (0.92, 2.06) | 1.09 (0.73, 1.63) | 0.31 |
| Model 3 | Ref | 1.08 (0.67, 1.76) | 0.83 (0.49, 1.40) | 1.46 (0.91, 2.33) | 0.95 (0.61, 1.49) | 0.81 |
| Quintiles of Food B-6 Intake | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | p-trend | |
| Dementia | ||||||
| Model 1 | Ref | 0.94 (0.67, 1.31) | 0.99 (0.72, 1.36) | 0.93 (0.68, 1.29) | 0.92 (0.67, 1.27) | 0.64 |
| Model 2 | Ref | 0.91 (0.65, 1.28) | 0.97 (0.70, 1.33) | 0.93 (0.67, 1.28) | 0.89 (0.64, 1.22) | 0.52 |
| Model 3 | Ref | 0.79 (0.50, 1.24) | 1.06 (0.70, 1.61) | 0.82 (0.53, 1.28) | 0.80 (0.51, 1.23) | 0.41 |
| AD | ||||||
| Model 1 | Ref | 0.78 (0.49, 1.24) | 0.93 (0.61, 1.41) | 0.90 (0.59, 1.37) | 1.07 (0.73, 1.58) | 0.60 |
| Model 2 | Ref | 0.73 (0.46, 1.16) | 0.88 (0.58, 1.34) | 0.85 (0.56, 1.60) | 0.96 (0.65, 1.43) | 0.93 |
| Model 3 | Ref | 0.78 (0.47, 1.28) | 1.06 (0.67, 1.68) | 0.91 (0.57, 1.45) | 0.84 (0.53, 1.35) | 0.70 |
Model 1- unadjusted; Model 2- adjusted for gender, education; Model 3- fully adjusted for gender, education, bmi (cont), total kcals (cont), physical activity, apoe, alcohol, smoking, MI, stroke, DM, and the other B-vitamins in quartiles treated as a continuous variables (17 = df).