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. 2013 May 6;210(5):917–931. doi: 10.1084/jem.20122308

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© 2013 Kirchberger et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — IL-23 signature genes are increased in aberrant crypt lesions of Hh+AOM-treated mice. (A) Treatment scheme (left) and H&E-stained invasive colorectal-carcinoma in Hh+AOM-treated 129SvEv.Rag^−/− mice (right; bar, 100 µm). Arrows represent atypical glands breaching the muscularis mucosa. (B) Quantitative PCR analysis showing levels of mRNA of the cytokines Il-23, Il-17, and Il-22, the matrix metalloproteinases Mmp9 and Mmp2, the EGF receptor ligand amphiregulin (Areg), and Hif1a, Vegfa, and Ptgs2 (Cox-2) in tumors versus surrounding normal tissue (n = 5–7). Graphs show a representative experiment out of two independently performed. *, P < 0.05; **, P < 0.01; ***, P < 0.001, paired Student’s t test.