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. 2013 May 6;210(5):917–931. doi: 10.1084/jem.20122308

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© 2013 Kirchberger et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — IL-22 drives cancer perpetuation. (A) Treatment scheme. (B) Spleen mass (left), colitis (middle), and typhlitis (right). Means (n = 9–14). Results are a pool of two independent experiments. (C) Representative photomicrographs of colons (bars, 200 µm). (D) Granulocyte frequencies (left) and numbers (right) in cLPs as analyzed by flow cytometry for Gr-1^hi, CD11b^hi, and F4-80⁻, Ly6C^int cells (n = 3–5). Data shown represent one out of two independent experiments. (E) CRC in antibody-treated Hh+AOM mice. Highest tumor grade per mouse. (F) Colonization with Hh. Results are a pool of two independent experiments (B, E, and F). Bars represent the mean value (B, D, and F). Significance refers to isotype control (B and E). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001, one-way ANOVA with Bonferroni’s post test (B) or Fisher’s square test (E).