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. 2013 May 6;210(5):987–1001. doi: 10.1084/jem.20121608

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© 2013 Singh et al.

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Figure 4. — Sirt1-deficient BM shows serial transplantation defects. (A) Survival plots from serial transfer experiments using BM from 4-OHT–treated Sirt1-E4^fl/fl, ERT2-Cre (SIRT1^Δ/Δ) and ERT2-Cre (Cre) control mice. Surviving mice were subjected to secondary transfer. Recipient animal numbers three per group for primary transfer and four per group for secondary transfer. (B) Tertiary transfer of Cre control BM (n = 8). (C) Contribution of CD45.2⁺ donor cells to recipient BM at the end of 1 and 2° transfer in surviving mice from A (left) and from a second independent experiment with WT (n = 7) and SIRT1^Δ/Δ (n = 9) mice (right). Error bars represent SD. ***, P ≤ 0.001.