A) Acute administration of citalopram, at 30 mg/kg but not 10 mg/kg, induced anxiogenic effect in elevated plus maze (n=8-10, per group). Values are means +/−SEM. * groups that differed significantly from vehicle-treated animals (p<0.05). B) Sub-chronically, citalopram increased the time spent in open-arm (n=9-10, per group). Values are means +/−SEM. * groups that differed significantly from vehicle-treated animals (p<0.05). C-D) Absence of effect of acute and sub-chronic, respectively, injections of citalopram on locomotor activity in the elevated zero maze. Values are means +/−SEM.