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. Author manuscript; available in PMC: 2013 May 7.
Published in final edited form as: Int J Neuropsychopharmacol. 2009 Dec 14;13(3):321–334. doi: 10.1017/S1461145709990630

Figure 5. Anxiolytic and antidepressant response of citalopram is abolished in CREBαΔ mice.

Figure 5

A) Citalopram induced an anxiolytic-like effect in wild-type animals in the elevated zero maze, while there was no effect in CREBαΔ mice (n=7-8). Values are means +/−SEM. * groups that differed significantly from respective saline treated animals (p<0.05). # groups that differed from wild-type animals(p<0.05).B) Sub-Chronic treatment with citalopram induced antidepressant-like effect in tail suspension in wild-type mice (n=6-10). Although CREB deletion elicited a decrease in time spent in immobility, this effect was not potentiated by citalopram. Values are means +/−SEM. *groups that differed significantly from respective saline treated animals (p<0.05).