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. Author manuscript; available in PMC: 2013 May 7.
Published in final edited form as: Int J Neuropsychopharmacol. 2009 Dec 14;13(3):321–334. doi: 10.1017/S1461145709990630

Figure 6. Anxiolytic and antidepressant response of citalopram is abolished in CREBαΔ mice.

Figure 6

A) Sub-chronic administration of citalopram treatment decreased the latency to consume peanut butter chips in the novel environment in both WT and CREBαΔ mutant mice (n=7-10). Moreover, saline-treated CREBαΔ mutant mice exhibited an increase in latency to feed in the novel environment. Values are means +/−SEM. * groups that differed significantly from respective saline treated animals (p<0.05). # groups that differed significantly from respective Wild-type animals (p<0.05). B) In the first home cage test, a single administration of citalopram increased the latency to feed in CREBαΔ mutant mice. Values are means +/−SEM. * groups that differed significantly from respective saline treated animals (p<0.05). C) No specific effect of citalopram or CREB deficiency was observed in the second home cage test. Values are means +/−SEM.