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Real time whole-body animal imaging was used to assess the retention of subcutaneously injected fluorescently-labeled PEG4-dopamine with or without various concentrations of Fe3+ solution. Images (A) and quantification of fluorescent signal (B) indicated rapid degradation in the group without Fe3+, improved retention for implants formed with 0.5 M Fe3+ solution, and maximal retention for implants formed with 2 M Fe3+ solution. Data are means ± SD; n=3.
