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(A) Hemophagocytes Noted on Bone Marrow (100X magnification). Paraffin immunohistochemistry for CD163 (a marker for histiocytes) performed on the bone marrow biopsy shows numerous activated histiocytes, many of which have round nuclei and ample cytoplasm. Occasional histiocytes show multiple nuclei, or lucencies, consistent with hemophagocytosis. (B) Family Tree and STXBP2 Gene Mutation Analysis.
