Fig. 6.

Cross-sectional OCT and en face RCM images of the EpiDermFT Skin Model. (A): Cross-sectional OCT image; all three layers (corneum, epidermal, and dermal) were resolved by OCT. (B): PS OCT image showing some moderate birefringence of the dermal layer. (C): Histology showing the detailed morphology of the skin layers. 100x magnified images show the cobblestone cells in the corneum, larger cells with visible nuclei in the epidermis, and the collagen fibers in the dermis. (D-G): RCM images showing tissue morphology at different depths: Cobblestone appearance of the corneum layer (D), polygonal cells in the epidermis (E), Dermal papillae at the dermal-epidermal junction (F), and collagen fibers in the upper dermis (G).