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. Author manuscript; available in PMC: 2013 May 7.
Published in final edited form as: J Allergy Clin Immunol. 2012 Dec 11;131(2):468–476. doi: 10.1016/j.jaci.2012.10.029

FIG 5.

FIG 5

Immune globulin production in vitro. PBMCs of subjects with CVID (n = 6) or family members (n = 6) with the same TACI mutations (C104R, A181E, S194X) or cells of healthy controls (n 5 7) were incubated with the indicated activators for 12 days, and IgG (A) or IgA (B) was determined. Relatives with TACI mutations had similar amounts of IgG and IgA production in comparison with control B cells (Mann-Whitney test P = .2 and .5, and ANOVA P = .1638), but subjects with CVID had impaired IgG (P = .04) and especially IgA secretion (P = .001) compared with controls.