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Mean serum nicotine concentrations (ng/ml) following nasal spray use. Measurements below the limit of quantitation (BLQ) were substituted as follows: 1) first of consecutive BLQ measurements was assigned a value of 1ng/ml with subsequent BLQ measurements assigned a value of 0ng/ml; 2) single BLQ measurements and BLQ measurements at baseline assigned a value of 0ng/ml.
