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. Author manuscript; available in PMC: 2013 May 7.
Published in final edited form as: J Allergy Clin Immunol. 2011 Apr 17;127(6):1360–7.e6. doi: 10.1016/j.jaci.2011.02.039

FIG 1.

FIG 1

Case-control allele frequency significance. SNP-based case-control significance is shown in negative log base 10 genome-wide analysis for (A) discovery- and (B) replication-inclusive CVID cohorts. (C) Subsequently, CVID cases with specific disease subphenotypes were compared with CVID cases without the subphenotype. The single-SNP tests are shown as single points. Multiple neighboring SNPs of similar significance boost confidence in the association, as shown in the strong peak on 6p22.1-p21.32 of the discovery case-control cohort. Conversely, the median significance P value is kept low by minimizing population stratification, which minimizes the genomic inflation factor.