Table 3.
Comparison of different categorization methods for predicting event-free survival at 2 years in patients alive and event free at 6 months (n = 76)
| Follow-up time for subpopulation predicted to progress | N (above, below) threshold or (slow, fast) response | Correctly classified,% | Positive predictive value,% | Negative predictive value,% |
|---|---|---|---|---|
| 3 months |
|
|
|
|
| > 10% BCR-ABL |
32, 44 |
67.1 |
81.8 |
46.9 |
| > 1% BCR-ABL |
51, 25 |
52.6 |
84.0 |
37.3 |
| > 0.1% BCR-ABL (MMR) |
63, 13 |
44.7 |
92.3* |
34.9 |
| 6 months |
|
|
|
|
| > 10% BCR-ABL |
26, 50 |
75.0 |
84.0 |
57.7 |
| > 1% BCR-ABL |
38, 38 |
64.5 |
84.2 |
44.7 |
| > 0.1% BCR-ABL (MMR) |
50, 26 |
56.6 |
88.5 |
40.0 |
| Slow (monophasic) responders | 27, 49 | 77.6* | 86.0 | 61.5* |
Abbreviation: MMR = major molecular response.
* The number in bold indicates the highest score for that column.