Figure 1. Effect of obesity on relaxation of mesenteric arteries to different agonists.

Cumulative concentration-response curves to anandamide (A), ACEA, CB₁ receptor-selective agonist (B), JWH-015, CB₂ receptor-selective agonist (C), capsaicin, vanilloid receptor agonist (D), acetylcholine (ACh), endothelium-dependent vasodilator (E) and sodium nitroprusside (SNP), endothelium-independent vasodilator (F) in U46619-precontracted mesenteric arteries from lean Zucker rats (LZRs) and obese Zucker rats (OZRs). Each point represents the mean ± SEM. *, P<0.05 vs. LZR. N = 6/group.