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. 2013 May 7;8(5):e63449. doi: 10.1371/journal.pone.0063449

Figure 2. Contribution of cannabinoid receptors activation to the vascular effects of anandamide.

Figure 2

In A, the vessels were pretreated with a CB1 antagonist (AM 251, 1 µM) and in B with a CB2 antagonist (AM 630, 1 µM) for 30 minutes. The relaxation to anandamide was evaluated in U46619-precontracted mesenteric arteries from lean Zucker rats (LZRs) and obese Zucker rats (OZRs). Each point represents the mean ± SEM. *, P<0.05 vs. LZR. #, P<0.05 vs. respective group in the absence of blockade. N = 6/group.