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. 2013 May 7;8(5):e63449. doi: 10.1371/journal.pone.0063449

Figure 4. Involvement of TRPV1 receptors on sensory C-fibres in anandamide responses.

Figure 4

In A, in vitro C-fiber desensitization was induced using the selective neurotoxin capsaicin (1 µM). In B and C, vessels were pretreated with the TRPV1 blockers, ruthenium red (30 µM, 30 minutes) and capsazepine, respectively (3 µM, 30 minutes). In D, vessels were pretreated with the calcitonin gene-related peptide (CGRP) receptor antagonist α-CGRP (8–37) (10 µM, 30 minutes). The relaxation to anandamide was evaluated in U46619-precontracted mesenteric arteries from lean Zucker rats (LZRs) and obese Zucker rats (OZRs). Each point represents the mean ± SEM. *P<0.05 vs. LZR, #P<0.05 vs. respective group in the absence of blockade. N = 6/group.