Table 2. GO enrichment analysis of SP+ and SP- secretory classes in yeast and human.

Organism	Secretory Type	GOID	Term	Corrected p-value
Yeast	SP+	GO:0071554	cell wall organization or biogenesis	9.06E-50
		GO:0070882	cellular cell wall organization or biogenesis	7.47E-49
		GO:0007047	cellular cell wall organization	4.41E-40
		GO:0045229	external encapsulating structure organization	4.41E-40
		GO:0071555	cell wall organization	4.41E-40
		GO:0071852	fungal-type cell wall organization or biogenesis	1.17E-28
	SP-	GO:0006810	transport	2.61E-137
		GO:0051234	establishment of localization	2.64E-133
		GO:0051179	localization	1.91E-123
		GO:0055085	transmembrane transport	2.80E-85
		GO:0016192	vesicle-mediated transport	1.20E-56
		GO:0071702	organic substance transport	1.18E-41
Human	SP+	GO:0005102	receptor binding	7.06E-140
		GO:0005125	cytokine activity	1.64E-84
		GO:0005179	hormone activity	1.03E-58
		GO:0005539	glycosaminoglycan binding	4.74E-58
		GO:0001871	pattern binding	7.90E-57
		GO:0030247	polysaccharide binding	7.90E-57
	SP-	GO:0004930	G-protein coupled receptor activity	0
		GO:0004984	olfactory receptor activity	0
		GO:0004888	transmembrane signaling receptor activity	9.81E-243
		GO:0038023	signaling receptor activity	2.91E-209
		GO:0004872	receptor activity	1.73E-156
		GO:0004871	signal transducer activity	8.90E-152

Significant GO terms (p-values<0.001) is listed here (see Materials and Methods). For the full list of the GO terms and corresponding statistics refer to the Table S10–13.