Figure 2. VBP15 reduces leukocyte infiltration in the OVA-induced model of acute allergic lung inflammation.

OVA-challenged mice were either left untreated or treated with oral doses of prednisone, VBP15 (20 mg/kg), or cherry syrup alone daily for 6 days. A group of non-challenged mice (naïve) was included in order to assess basal inflammatory parameters. Lung tissue and BAL cells underwent FACS analysis to determine the number of infiltrating eosinophils (A and C) and effector/memory CD4+T cells (B and D). Bar graphs represent mean (±SE) cell numbers. Percentages indicate percentage reduction compared to vehicle control. *p<0.05; **p<0.01; ***p<.001 compared to syrup group with n = 5 mice per group.