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. 2013 May 7;8(5):e63572. doi: 10.1371/journal.pone.0063572

Figure 1. Chemical structure and antiproliferative activity against CCRF-CEM cells of acridone derivative 2-aminoacetamido-10-(3, 5-dimethoxy)-benzyl-9(10H)-acridone hydrochloride (8a).

Figure 1

(A) Chemical structure of 8a. (B) Viability of CCRF-CEM cells after 24 h of exposure to 8a. The viability of the control cells, which were exposed to DMSO only, was set as 100%. n = 6, *p<0.05 compared with vehicle control. (C) Flow cytometric analysis of phosphatidylserine externalization (annexin V-binding) and cell membrane integrity (PI staining). CCRF-CEM cells were treated with 8a at 0.5 µM for 24 h.