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. 2013 May 7;8(5):e62531. doi: 10.1371/journal.pone.0062531

Figure 5. C3 and C5a plasma level and mRNA expression in muscle and liver of genes implicated in substrate utilization.

Figure 5

Plasma levels of C3 (A) and C5a (B) in WT and C5aRKO on chow and DIO diet for n = 8–12 per group. Gene expression in quadriceps muscle tissue (C) and liver (D) for fatty acid transporter (CD36), fatty acid synthase (FAS), lipoprotein lipase (LPL), diacylglycerolacyltransferase-1 (DGAT1), diacylglycerolacyltransferase-2 (DGAT2) and peroxisome-proliferator activated receptor gamma (PPARG) were measured in WT CHOW diet (open bars), C5aRKO CHOW (solid bars), WT diet-induced obesity (DIO) diet (checkered bars) and C5aRKO DIO (striped bars) for n = 6–12 per group. Results are expressed as means ± SEM; statistical differences were determined by t-test, where *P<0.05 and**P<0.001 and ***P<0.0001 for C5aRKO vs WT on the same diet, unless otherwise indicated.