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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Mol Cell Cardiol. 2013 Feb 27;59:86–94. doi: 10.1016/j.yjmcc.2013.02.010

Figure 2. Expression of CYP isoforms inhibited by cimetidine in the DA.

Figure 2

A. Stage-specific expression of the CYP enzymes that are inhibited by cimetidine was analyzed by qPCR. Expression levels are displayed in relationship to the housekeeping gene rpL7. * p<0.01. B. Localization of the mouse homologues of CYP3A4 protein in the unconstricted fetal DA (d19) and in the closed neonatal DA (P1; 200×, 400×). Negative control study on a parallel section of P1 tissues is shown in the third panel (200×).