Figure 5. Human T cells bearing the αerbB2DAP10ζCD27 CAR inhibit tumor growth in mice.

(a) CAR-expressing human T cells were injected on days 0, 1 and 2 intravenously into NOD-SCID mice injected subcutaneously on day 0 with 24JK-erbB2 sarcomas, and tumor growth monitored (9–10 mice/group). (b,c) Localization of T cells was determined on dissociated tumor and tissues on day 4 of tumor growth using flow cytometry (5 mice/group). (Error bars = SEM). *p<0.05, **p<0.005, NS = not significant.