Table 1.

Clinical, confocal and histological characterization of the study cases.

Cases	Age (years)	Sex	Smoking History	Smoking Details	Current Heavy Drinka	Site	Samples	Nuclear features in confocal imaging			H&E histology
								Density	Cell-Cell spacing	Size and shape
Patient 1	82	M	FS	48 Pack-year, quit for 10 years	N	Tongue	# 1	markedly increased	irregular	variable	Severe dysplasia
Patient 2	50	M	FS	31 Pack-year, quit for 1 year	N	Floor of Mouth	# 1	normal	regular	uniform	Normal mucosa
Patient3	68	M	S	67 Pack-year	N	Floor of Mouth	# 1	markedly increased	irregular	variable	Severe dysplasia
							# 2	slightly increased	irregular	uniform	Moderate dysplasia
							# 3	normal	regular	uniform	Hyperplasia
							# 4	normal	regular	uniform	Hyperplasia
							# 5	slightly increased	irregular	uniform	Moderate dysplasia
							# 6	markedly increased	irregular	variable	Severe dysplasia
Patient 4	61	M	FS	25 Pack-year, quit for 13 years	N	Soft Palate	# 1	normal	regular	uniform	Mild dysplasia
							# 2	normal	regular	uniform	Hyperplasia
							# 3	normal	regular	uniform	Hyperplasia
Patient 5	42	F	NS	-	N	Tongue	# 1	normal	regular	uniform	Normal mucosa
							# 2	normal	regular	uniform	Normal mucosa
							# 3	normal	regular	uniform	Normal mucosa
							# 4	normal	regular	uniform	Normal mucosa
Patient 6	70	M	FS	50 Pack-year, quit for 1 year	N	Soft Palate	# 1	normal	regular	uniform	Mild dysplasia
							# 2	normal	regular	uniform	Moderate dysplasia
Patient 7	34	F	NS	-	N	Tongue	# 1	normal	regular	uniform	Normal mucosa
							# 2	normal	regular	uniform	Normal mucosa
Patient 8	83	F	NS	-	N	Tongue	# 1	normal	regular	uniform	Mild dysplasia
							# 2	normal	regular	uniform	Mild dysplasia
Patient 9	68	F	FS	30 Pack-year, quit for 28 yrs	N	Tongue	# 1	markedly increased	irregular	variable	Severe dysplasia
							# 2	markedly increased	irregular	variable	Severe dysplasia
Patient 10	64	M	S	46 Pack-year	Y	Soft Palate	# 1	normal	regular	uniform	Mild dysplasia
							# 2	markedly increased	irregular	variable	Severe dysplasia
Paient11	49	M	NS	-	N	Tongue	# 1	normal	regular	uniform	Normal mucosa
							# 2	normal	regular	uniform	Normal mucosa
Patient 12	70	M	FS	33 Pack-year, quit for 18 years	N	Tongue	# 1	normal	regular	uniform	Normal mucosa
							# 2	normal	regular	uniform	Normal mucosa
Patient 13	84	M	FS	43 Pack-year, quit for 24 years	N	Tongue	# 1	markedly increased	irregular	variable	Severe dysplasia
							# 2	markedly increased	irregular	variable	Severe dysplasia

^aCurrent heavy drinker: ≥3 units/day; 1 unit = 1 glass of wine, 1 can of beer, or 1 shot of liqour