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. Author manuscript; available in PMC: 2014 May 3.
Published in final edited form as: Biochem Biophys Res Commun. 2013 Apr 2;434(2):352–356. doi: 10.1016/j.bbrc.2013.03.077

Figure 1.

Figure 1

Depletion of FBXW7 in HCT116 cells leads to Epithelial-mesenchymal transition. (A) Morphology comparison of HCT116 FBXW7−/− and its control cells under bright field. (B) Western blot analysis of indicated EMT markers in HCT116 FBXW7−/− and its control cells. (C) Immunofluorescence staining for indicated EMT markers (Green) in HCT116 FBXW7−/− and its control cells. DAPI staining is blue. Scale bar is 20μm. (D) qRT-PCR analysis of Twist-1 and Snail-1 expression in HCT116 FBXW7−/− and its control cells. Data were presented as means ± Standard deviation from three independent experiments in triplicates. **P <0.01 was obtained from Student’s t-test.