Figure 8. Myocardial triglycerides and left ventricular function.

The increased myocardial triglyceride levels are highly negatively correlated with EF in both obese ( ) and EtOH-consuming ( ) mice. However, the slope of the decline in EF with increasing cardiac triglyceride content is much steeper with EtOH consumption than with obesity. Accordingly, although high fat diet (HFD)-fed and 18% EtOH-consuming mice have similar increases in cardiac TG content, reflecting similar increases in facilitated LCFA uptake, the E18 mice have a much greater reduction in ejection fraction.