Table 2.
The distribution of pathology scores and laboratory data in the patients with CGD. Panel A shows data for all CGD biopsies (n= 366) whereas Panel B shows data on 94 CGD biopsies with concomitant acute rejection.
| Panel A: All CGD biopsies (n=366)* | ||||
|---|---|---|---|---|
| Biopsy Score | 0 | 1 | 2 | 3 |
| i (interstitial inflammation) | 45% | 22% | 13% | 20% |
| t (tubulitis) | 44% | 21% | 19% | 15% |
| ci (interstitial fibrosis) | 33% | 43% | 19% | 4% |
| ct (tubular atrophy) | 25% | 51% | 19% | 5% |
| cv (vascular fibrosis) | 63% | 19% | 16% | 2% |
| cg (glomerulopathy) | 88% | 7% | 2% | 3% |
| ah (arteriolar hyaline thickening) | 71% | 20% | 6% | 3% |
| v (intimal artertitis) | 89% | 9% | 1% | 1% |
| g (glomerulitis) | 86% | 8% | 5% | 1% |
| Other Laboratory data | Focal Positive | Diffuse Positive | Negative | Not Done |
|---|---|---|---|---|
| C4D staining | 8% | 13% | 70% | 9% |
| Panel B: CGD biopsies with concomitant AR (n=94) | ||||
|---|---|---|---|---|
| 0 | 1 | 2 | 3 | |
| Biopsy Score | ||||
| i (interstitial inflammation) | 0% | 0% | 36% | 64% |
| t (tubulitis) | 0% | 0% | 49% | 51% |
| ci (interstitial fibrosis) | 30% | 44% | 21% | 4% |
| ct (tubular atrophy) | 27% | 48% | 20% | 5% |
| cv (vascular fibrosis) | 75% | 10% | 12% | 3% |
| cg (glomerulopathy) | 94% | 4% | 1% | 1% |
| ah (arteriolar hyaline thickening) | 77% | 19% | 3% | 1% |
| v (intimal artertitis) | 71% | 24% | 2% | 3% |
| g (glomerulitis) | 85% | 9% | 5% | 1% |
| Other Laboratory data | Focal Positive | Diffuse Positive | Negative | Not Done |
|---|---|---|---|---|
| C4D staining positive | 17% | 24% | 59% | <1% |
*
Less than (30) 1% missing biopsy scores.
ci and ct scores correlated (Spearman correlation coefficient=0.88, p<0.0001); i and t scores correlated (Spearman correlation coefficient=0.81, p<0.0001)
ci and ct scores correlated (Spearman correlation coefficient=0.87, p<0.0001); i and t scores correlated (Spearman correlation coefficient=0.55, p<0.0001)