Table 3.
Characteristic | All n= 2,336 | Test Cohort n =979 | Non-Test Cohort n=1,357 | p-value |
---|---|---|---|---|
0.05 | ||||
Ethnicity: White | 75 % | 77 % | 74 % | |
Black | 19 % | 17 % | 20 % | |
Asian | 3 % | 3 % | 3 % | |
Other | 2 % | 2 % | 3 % | |
Not Known | <1 % | < 1% | 0 % | |
Hispanic | 2 % | 2 % | 1 % | 0.99 |
Male | 63 % | 63 % | 63 % | 0.89 |
Mean age at enrollment in years | 49 ±14 | 49 ±14 | 49 ±14 | 0.20 |
Cause of End Stage Kidney Disease: | 0.87 | |||
Diabetes | 28 % | 31 % | 26 % | |
Glomerular disease | 21 % | 20 % | 21 % | |
HTN | 14 % | 12 % | 16 % | |
Polycystic kidney disease | 13 % | 12 % | 13 % | |
Other | 21 % | 21 % | 21 % | |
Unknown | 3 % | 4 % | 3 % | |
History of diabetes | 36% | 38 % | 35 % | 0.89 |
Living donor transplant | 58 % | 59 % | 57 % | 0.84 |
Mean donor age in years | 40 ± 14 | 40 ± 14 | 40 ± 14 | 0.07 |
Male donor* | 48 % | 46 % | 49 % | 0.12 |
Cold Ischemia time >24 h* | 8 % | 7 % | 9 % | 0.25 |
Prior kidney Transplant | 13 % | 14 % | 13 % | 0.63 |
Need for dialysis in the first 14 days post transplant* | 10% | 8 % | 10 % | 0.005 |
Final PRA present * | 42% | 35 % | 47 % | <0.001 |
T or B Crossmatch positive* | 6 % | 5 % | 6 % | 0.92 |
Plasmapheresis prior to transplants | 3 % | 3% | 2% | 0.35 |
Zero HLA mismatches | 12 % | 11 % | 12 % | 0.45 |
Antibody Induction: | <0.0001 | |||
Monoclonal | 44 % | 40 % | 47 % | |
None | 4 % | 1 % | 5 % | |
Other | 3 % | 4 % | 2 % | |
Polyclonal | 50 % | 54 % | 46 % | |
Smoking status:* | ||||
Never | 58 % | 60 % | 57 % | 0.39 |
Past | 32 % | 31 % | 33 % | |
Current | 9 % | 9 % | 10 % | |
Pre-emptive transplant | 29 % | 31 % | 26 % | |
Steroid withdrawal by day 14 post-transplant | 39 % | 48 % | 30 % | 0.58 |
Use of Mycophenolate Mofetil | 99% | 99 % | 99 % | |
CNI type: | 0.03 | |||
Cyclosporine | 28 % | 22 % | 35 % | 0.90 |
Tacrolimus | 69 % | 75 % | 62 % | 0.58 |
None | 3 % | 3 % | 3 % | |
SPK** | 6 % | 6 % | 5 % | |
Prior Non-kidney Transplants* | 10 % | 11 % | 9 % | 0.90 |
CMV Recipient/Donor Status* | 0.88 | |||
Recipient (−)/Donor (−) | 20 % | 22 % | 19 % | 0.43 |
Recipient (+) | 63 % | 62 % | 64 % | |
Recipient (−)/Donor (+) | 17 % | 16 % | 17 % |
Missing data: Living donor gender missing in 7 subjects, need for dialysis in the first 14 days post-transplant missing in 4 subjects, Cold Ischemia time missing in 209 subjects, Final PRA missing in 7 subjects, Plasmapheresis prior to transplant missing in 57 subjects, B/T cell crossmatch missing in 51 subjects, Smoking status missing in 7 subject, Use of Mycophenolate Mofetil and CNI type was missing in 215 subjects, Prior non-kidney transplant missing in 44 subjects, CMV recipient/donor status missing in 44 subjects.
SPK= Simultaneous kidney pancreas transplants