Table 5. Adjusted Risk Factors for Infectious Complications and Non-Infectious Complications.

	Infectious Complications		Non-Infectious Complications
Variable	Adjusted IRR* (95% CI)	p value	Adjusted IRR* (95% CI)	p value
Age categories
<1 year	1		1
≥1 to 7 years	0.89(0.54-1.48)	0.66	0.75(059-0.97)	0.03
>7 to 13 years	0.56(0.30-1.56)	0.07	0.43(0.30-0.59)	<0.001
>13 years	0.56(0.32-0.98)	0.04	0.47(0.35-0.63)	<0.001
Site of PICC Insertion **
Upper Extremity	1		1
Lower extremity	0.71(0.32-1.56)	0.41	1.21(0.85-1.70)	0.29
Head and neck	0.45(0.24-0.83)	0.01	1.26(0.99-1.61)	0.06
Tip Location
Central	1		1
Non-Central***	0.75(0.34-1.50)	0.38	4.56(3.67-5.61)	<0.001
PICU Exposure
No	1		1
Yes	2.23(1.43-3.48)	<0.001	1.11(0.89-1.38)	0.35
Line Year	0.86(0.78-0.95)	0.003	0.86(0.82-0.91)	<0.001

Abbreviations: CI, confidence interval; IRR, incidence rate ratio; PICU, pediatric intensive care unit.

^*Adjusted for catheter dwell time using cubic spline terms, sex, and indication for catheter insertion

^**Insertion sites for PICCs were classified as upper extremity, lower extremity and head and neck based on where the PICC was placed

^***Catheter tip locations were categorized as non-central if they did not reside in the superior vena cava, right atrium, or high inferior vena cava or above the level of the diaphragm for lower extremity catheters.