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. 2013 May 7;8(5):e62969. doi: 10.1371/journal.pone.0062969

Figure 2. Placental DNA methylation of genes involved in cortisol signalling and bioavailability.

Figure 2

DNA methylation at CpG sites within A) exon 1D promoter of the nuclear receptor subfamily 3, group C, member 1 (NR3C1), B) corticotropin releasing hormone (CRH) and C) CRH binding protein (CRHBP) genes. Control, early onset pre-eclampsia (EOPET), late onset pre-eclampsia (LOPET) and normotensive intrauterine growth restriction (nIUGR) placentae are compared. Median and interquartile ranges are given based on average assay CpG methylation measured by bisulfite pyrosequencing. *P<0.05, **P<0.01.