Table 1. Patient characteristics for cases assessed by bisulfite pyrosequencing.
Parameter | Controls n = 111 | EOPET n = 19 | LOPET n = 18 | nIUGR n = 13 |
Birth weight (g) | 2590±989 | 1399±621 | 2742±798 | 2132±513 |
Birth weight (SD) | 0.06±0.07 | −1.51±0.22*** | −0.73±0.29** | −1.67±0.20*** |
Co-existing IUGR | – | 14/19 | 5/18 | – |
Gestational age (weeks) | 35.09±4.21 | 31.93±3.27* | 37.47±2.29* | 36.43±2.31 |
Maternal age (years) | 33.10±4.74 | 34.16±6.01 | 33.49±5.47 | 34.64±5.26 |
Female: Male ratio | 55∶56 | 7∶12 | 10∶8 | 9∶4 |
Mode of delivery | ||||
Labour | 46 | 4 | 9 | 5 |
No Labour | 8 | 6 | 3 | 4 |
Undefined | 57 | 9 | 6 | 4 |
Birth weight statistics are based on standard deviation (SD) points relative to gestational age and gender matched normal birth weight ranges. Gestational age values are given at birth. Data are mean ± SD. The mode of delivery is characterised as ‘Labour’ (spontaneous or induced vaginal delivery), ‘No Labour’ (elective caesarean section) or, ‘Undefined’: emergency caesarean section or unknown. EOPET: early onset pre-eclampsia, LOPET: late onset pre-eclampsia, nIUGR: normotensive intrauterine growth restriction,
P<0.05,
P<0.01,
P<0.001, compared to controls.