Table 2. Illumina Infinium HumanMethylation450 BeadChip array data.

Gene	Chromosome location	CpG of interest	Gene region	CpG island?	DNA methylation (β value)		Δ β	P-value
					Control	EOPET
NR3C1	ch5 (q31.3)	cg14558428	exon 1D promoter	Y	0.14±0.08	0.23±0.12	0.09	0.01
NR3C1	ch5 (q31.3)	cg24026230	exon 1D promoter	Y	0.11±0.06	0.19±0.13	0.08	0.02
CRH	ch8 (q13.1)	cg23409074	exon 1 (5′ UTR)	N	0.37±0.12	0.29±0.06	−0.08	0.03
CRHBP	ch5 (q13.3)	cg13777717	intron 3	Y	0.40±0.08	0.48±0.07	0.08	0.001
CYP11A1	ch15 (q24.1)	cg06285340	exon 1	N	0.54±0.03	0.42±0.04	−0.12	<0.0001
HSD3B1	ch1 (p12)	cg16175792	exon 2	N	0.82±0.02	0.69±0.05	−0.13	<0.0001
TEAD3	ch6 (p21.31)	cg10893014	intron 1	N	0.60±0.06	0.39±0.10	−0.21	<0.0001
CYP19	ch15 (p21.2)	cg15329467	placental-specific exon 1.1 promoter	N	0.56±0.05	0.46±0.05	−0.10	<0.0001

The Illumina CpG of interest, gene location and CpG island (defined as length >200 base pairs, 50% GC content and >0.6 CG ratio) association is provided. Mean ± SD methylation β values and P-values are given for each gene for control (n = 19) and early onset pre-eclampsia (EOPET; n = 19) placental samples. NR3C1: nuclear receptor subfamily 3, group C, member 1, CRHBP: corticotropin releasing hormone (CRH) binding protein: HSD3B1∶3β-hydroxy-delta-5-steroid dehydrogenase type 1, TEAD3: TEA domain family member 3.