Figure 2.

Overexpression of specific reprogramming factors reprograms fibroblasts into other type of cells. Fibroblasts can be converted into iPSCs,⁷⁾ skeletal muscle cells,³⁸⁾ neurons,¹⁷⁾ neural progenitors,³⁹⁾ cardiomyocytes,¹⁴⁾ and hepatocytes¹⁵⁾ by transduction of lineage-specific transcription factors (parentheses).