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. 2013 Mar 11;89(3):118–128. doi: 10.2183/pjab.89.118

Figure 5.

Figure 5.

Gata4/Mef2c/Tbx5 Injection into mouse infarct hearts. Strategy for in vivo cardiac reprogramming by Gata4, Mef2c and Tbx5. Myocardial infarction was generated by coronary artery ligation in mouse. A pool of Gata4, Mef2c and Tbx5 was directly injected into the mouse hearts immediately after coronary artery ligation. Gene transfer of reprogramming factors induced new cardiomyocyte generation in a subset of fibroblasts in infarcted hearts.