Table 3.

Cox-regression multivariate analysis of predictive factors for time to brain metastases (TTBM) from initial distant metastases

Characteristics	HR (95% C.I.)	P-value
Age at first diagnosis of primary disease	1.001 (0.985-1.018)	0.863
Stage IV at initial diagnosis of primary BC	0.843 (0.475-1.495)	0.559
Site of initial distant metastases
Bone	0.695 (0.498-0.969)	0.033
Lung	1.138 (0.811-1.597)	0.453
Liver	1.431 (0.934-2.190)	0.099
Subtype with trastuzumab effect
HR-positive/HER2-negative	reference
HER2-positive withoutTrastuzumab	1.892 (1.177-3.040)	0.008
HER2-positive with Trastuzumab	1.064 (0.650-1.741)	0.656
TNBC	1.652 (1.071-2.546)	0.023