Table 1.
Reported plasmablastic lymphoma cases in HIV seronegative, immunocompetent patients with outcomes
| Report | Demographics | Location | EBV + | Treatment regimen | Prognosis |
|---|---|---|---|---|---|
| Delecluse et al. 1997 | 75 F | Gingiva | UNK | RT (UNK) | ↓ 3 mo * |
| Pruneri et al. 1998 | 53 F | Gastric | UNK | PROMACE / cytaBOM x 6 cycles | ↑19 mo |
| Nguyen et al. 2003 | 42 M | Nasal cavity Sinuses | (+) | Hyper-CVAD → RT (40 Gy) | ↑ 6 mo |
| Colomo et al. 2004 | 56 F | Oral Mucosa | (−) | UNK | UNK |
| 86 F | Maxillary Sinus | (+) | UNK | ↓ 4 mo | |
| 82 M | Lymph Node | (+) | UNK | UNK | |
| Lin et al. 2004 | 82 M | Cervical LN | (+) | CHOP x 6 cycles | UNK |
| Teruya-Feldstein et al. 2004 | 56 M | Sigmoid colon | (−) | CODOX/M-IVAC | ↓ 3 mo |
| 23 M | Neck mass, sinus | UNK | Hyper-CVAD, | ↓12 mo | |
| 49 M | Bone | PBSCT | ↓ 14 mo | ||
| 61 M | Liver, lung | (−) | CHOP x 6 cycles | ↓ 12 mo | |
| (+) | CODOX/M-IVAC | ||||
| Scheper et al. 2005 | 49 M | Mandible | (+) | UNK | UNK |
| Kravetz et al. 2006 | 66 M | Upper Extremity | (+) | Hyper-CVAD | ↑ 15 mo |
| Lee et al. 2006 | 66 M | Gingival Mass | (−) | Chemotherapy → RT (UNK) | ↓ 8 mo |
| Masgala et al. 2007 | 67 F | Visceral cranium, cervix, thorax | (−) | Cisplatin, 5-FU, leukovorin x 6 cycles | ↓ 23 mo |
| → CHOP x 6 cycles | |||||
| → CHOP-bleomycin | |||||
| → RT (2000 Gy) | |||||
| Kim et al. 2009 | 67 M | Terminal ileum | (−) | Surgery | ↓ 3 mo |
| 66 M | Oral cavity | (−) | Chemotherapy → | ↓ 8 mo | |
| 8 M | Tonsil | (−) | RT (UNK) | ↑ 36 mo | |
| 72 F | Paranasal sinus | (+) | Chemotherapy | ↑ 6 mo | |
| 61 M | Stomach | (−) | (UNK) | ↓ 3 mo | |
| 13 M | Meninges | (−) | Chemotherapy (UNK) Surgery | ↓ 7 mo | |
| Chemotherapy → RT (UNK) | |||||
| Takahashi et al. 2009 | 76 M | Retroperitoneum | (+) | Prednisolone | ↓ 35 days |
| Thakral et al. 2009 | 84 F | Psoas muscle | (−) | RT (UNK) | ↓ 1 mo |
| Cha et al. 2010 | 60 M | Jejunum | (−) | CHOP x 6 cycles | ↑ 24 mo |
| → ESHAP salvage | |||||
| → RT (UNK) | |||||
| Gogia and Bakhshi 2010 | 2 F | Jaw - Mandible | UNK | Chemotherapy (UNK) | ↓ sepsis |
| → RT (4 Gy) | |||||
| Khurana and Jaipota 2010 | 55 M | Cervical LN | UNK | CHOP | UNK |
| Lipstein et al. 2010 | 68 M | Cervical LN | (−) | R-CHOP, DICE, R-CBortP | ↓ 1 mo |
| Mihaljevic et al. 2011 | 60 M | Gastric | (−) | CHOP | ↓ 1 mo |
| Guan et al. 2011 | 58 M | Posterior teeth mucosa | (−) | Chemotherapy → XRT | ↓ 1 mo |
| Brahmania et al. 2011 | 59 M | Ano-rectal junction | (−) | CHOP x 3 cycles → XRT | ↑ 5 years |
| Mondal et al. 2011 | 47 F | Humerus | UNK | CHOP x 3 cycles | ↑ 12 mo |
| Mansoor et al. 2012 | 77 F | Cecal/Lung/LN | (−) | High dose steroids | ↓ 3 weeks |
| Present Case 2012 | 24 M | Maxillary Sinus | (+) | Hyper-CVAD → RT (45 Gy) | ↑ 4 years |
RT – radiotherapy, UNK – unknown, ↑ alive, ↓ died of disease, EBV – Epstein-Barr virus, HIV – Human Immunodeficiency Virus, M – male, F – female, y – years old, LN – lymph nodes, * dead of unrelated causes, Gy – gray (unit), PBSCT – peripheral blood stem cell transplant.