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. 2013 Apr 23;139(2):205–218. doi: 10.1111/imm.12071

Figure 5.

Figure 5

Effect of 2-chloroadenosine (2-CA) on airway inflammation and remodelling after the seventh antigen challenge in IgE-sensitized mice. (a) Effect of treatment with 2-CA on inflammatory cell number in bronchoalveolar lavage fluid 24 hr after the seventh challenge. (b) Effect of treatment with 2-CA on increased levels of interleukin-4 (IL-4) (i), IL-5 (ii) and IL-13 (iii) in the lung tissue supernatant 24 hr after the seventh challenge. (c) Effect of treatment with 2-CA on airway inflammation (i), epithelial area (ii), PAS+ area (iii), fibrosis area (iv), total collagen (v) and α-SMA+ area (vi) 24 hr after the seventh challenge. Results shown are from one experiment representative of two independent trials. Each value is the mean ± SEM of six or seven animals. #P < 0·05 and ##P < 0·01 compared with the OE-1 (7th) + vehicle group. Total, all cells; Mac, macrophages; Lym, lymphocytes; Neu, neutrophils; Eos, eosinophils.