Figure 2.

Graphical representation of hypothesis on gene-gene interactions. Attributes inside the large rectangular box are the variables included in the statistical model. Age, which is associated with NEO scores, is reflective of both genetic and environmental factors associated with aging. As genetics factors outweigh the environmental factors in individuals enriched for longevity, SNP-by-age interaction term in the model may imply gene-gene interaction which plays important roles in personality traits, as related to longevity.