Table 3.

Mediation Proportion for the Effect of Magnesium Intake on CHD Risk Explained by Hypertension, Diabetes, and High Cholesterol

	RR (95% CI) per 100 mg	Mediation Proportion (95% CI)
Total CHD
Base model*	0.83 (0.74 to 0.94)
Base model+hypertension	0.88 (0.78 to 0.99)	29 (11 to 47)
Base model+diabetes	0.85 (0.75 to 0.95)	8 (2 to 14)
Base model+high cholesterol	0.83 (0.74 to 0.93)	N/A*
Fatal CHD
Base model*	0.70 (0.56 to 0.87)
Base model+hypertension	0.76 (0.62 to 0.94)	23 (10 to 36)
Base model+diabetes	0.71 (0.57 to 0.87)	3 (−0.9 to 7)
Base model+high cholesterol	0.70 (0.56 to 0.86)	N/A*

CHD indicates coronary heart disease; RR, relative risk; CI, confidence interval; BMI, body mass index; MI, myocardial infarction.

^*RR adjusted for age, total calories, smoking, BMI, parental history of MI, alcohol intake, physical activity, menopausal therapy, multivitamin use, and intake of omega‐3 fats, polyunsaturated:saturated fat, trans fat, dietary cholesterol, calcium, cereal fiber, potassium and vitamin D.

^*Mediation proportion not calculated because the addition of intermediate variables to the base model did not attenuate the RR.